The Science

 

Scientists have recently developed an innovative method to extract specific components from hops that may aid in preventing weight gain and promoting fat loss. Using a patent-pending process, they have created a proprietary product called Matured Hop Extract (MHE3™).
This advanced extraction technique enhances the potency of the active ingredients, potentially making them more effective at supporting fat burning, healthy weight management, and the body’s natural functions.

The Research data on Hops Extract

2016:  Matured hop extract reduces body fat in healthy overweight humans: a randomized, double-blind, placebo-controlled parallel group study

In the active group, a significant reduction in visceral fat area was observed at both 8 and 12 weeks, along with a decrease in total fat area at 12 weeks, compared to the placebo group. Additionally, the active group showed a concurrent reduction in body fat ratio relative to the placebo group. No adverse events related to the test beverages were reported, and no clinically significant abnormalities in circulatory, blood, or urine parameters were observed in either group.

2018:  Matured Hop-Derived Bitter Components in Beer Improve Hippocampus-Dependent Memory Through Activation of the Vagus Nerve

Our findings indicate that MHBA enhances memory function by stimulating the vagus nerve and increasing norepinephrine (NE) release in the hippocampus. Activating the vagus nerve through the consumption of food materials containing MHBA may offer a safe and effective strategy for improving cognitive function.

2019:  Effects of Hop Bitter Acids, Bitter Components in Beer, on Cognition in Healthy Adults: A Randomized Controlled Trial

This study is the first to clinically evaluate the effects of bitter compounds found in beer on cognition, subjective mood, and mental fatigue. The results suggest that hop-derived bitter acids may have positive effects on cognition and mood state.

2020:  Hop bitter acids containing a β‑carbonyl moiety prevent inflammation‑induced cognitive decline via the vagus nerve and noradrenergic system

Bitter acids containing a β-tricarbonyl moiety can suppress microglial activation and improve memory impairments caused by inflammation or Alzheimer’s disease (AD) pathology. These effects are mediated through the activation of the gut-brain axis and the noradrenergic system. Supplements incorporating hop bitter acids, such as MHBAs, may represent a promising new approach for preventing cognitive decline and dementia.

2020:  Supplementation with Matured Hop Bitter Acids Improves Cognitive Performance and Mood State in Healthy Older Adults with Subjective Cognitive Decline

This study indicates that MHBA consumption enhances cognitive function, attention, and mood in older adults. Participants who consumed mature hop bitter acids demonstrated significant improvements in cognitive performance, particularly in attention and memory. These cognitive benefits are thought to be associated with the activation of dopamine neurotransmission, which supports memory processes in the hippocampus and cognitive functions in the prefrontal cortex.